✦ LIBER ✦

A labelled hypocholesteremic agent, preparation OF 2-(2-pyridine)-1-(3-chlorophenyl)-2-phenyl-1-methylethanol uniformly tritiated on the 2-phenyl ring

✍ Scribed by D. W. Hansen Jr.; E. Den Van Eeckhout; J. C. Drach; J. H. Burckhalter; J. K. Sinsheiraer

Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 234 KB
Volume: 10
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590100205

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✦ Synopsis

Abstract

2‐(2‐Pyridine)‐1‐(3‐chlorophenyl)‐2‐phenyl‐1‐methylethanol (I), containing tritium uniformly distributed in the 2‐phenyl ring, was synthesized in two steps with tritiated benzene as the labelled starting material.

An improved procedure was employed for the coupling of m‐chloroacetophenone and 2‐benzylpyridine. The higher melting of two enantiomeric pairs, known for its hypocholesteremic activity in rats, was isolated and found to have a chemical purity of >95% and a specific activity of 0.11 mCi/mmole.

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