Metabolic engineering ofEscherichia colito produce (2S, 3R, 4S)-4-hydroxyisoleucine
✍ Scribed by Sergey V. Smirnov; Tomohiro Kodera; Natalya N. Samsonova; Veronika А. Kotlyarovа; Natalya Yu Rushkevich; Аlexander D. Kivero; Pavel M. Sokolov; Makoto Hibi; Jun Ogawa; Sakayu Shimizu
- Book ID
- 105952827
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 441 KB
- Volume
- 88
- Category
- Article
- ISSN
- 1432-0614
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## Abstract A series of stereochemically defined analogues of (2__S__,3__R__,4__S__)‐4‐hydroxyisoleucine and related α‐hydroxy acids have been prepared by multi‐step routes from D‐glucose, whereas ketolization between TBDMS‐protected hydroxypropanone and ethyl isocyanoacetate led to racemic analogu