ChemInform Abstract: Synthesis of Hydantoin Analogues of (2S,3R,4S)-4-Hydroxyisoleucine with Insulinotropic Properties.
✍ Scribed by Didier Sergent; Qian Wang; N. Andre Sasaki; Jamal Ouazzani
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 28 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Abstract A series of stereochemically defined analogues of (2__S__,3__R__,4__S__)‐4‐hydroxyisoleucine and related α‐hydroxy acids have been prepared by multi‐step routes from D‐glucose, whereas ketolization between TBDMS‐protected hydroxypropanone and ethyl isocyanoacetate led to racemic analogu
## Abstract (2__S__,3__R__,4__S__)‐4‐Hydroxyisoleucine, which exhibits remarkable insulinotropic activity, is expected to be a potent drug to treat type II diabetes. We propose herein a four‐step synthesis of the enantiopure natural product on the basis of successive Mannich condensation, catalytic
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