๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Meta-analysis in clinical trials

โœ Scribed by Rebecca DerSimonian; Nan Laird


Book ID
119143300
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
668 KB
Volume
7
Category
Article
ISSN
0197-2456

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Randomized trials are effective and usually unbiased for showing the average results in a selected outcome variable for treatment A versus treatment B, and meta-analyses produce an average of these averages. The results of both the trials and meta-analyses are often pragmatically unsatisfactory, how

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In this paper we discusa empirical Bayes methods for combining evidence from a series of clinical experiments comparing two treatments. The approach is bawd on a random effects model for the treatment effects. We describe two nonparametric empirical Bayes procedures for estimating the effect sizes i

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The randomized clinical trial is the gold standard methodology for evaluating treatment interventions. The randomized trial is a prospective experimental study, the embodiment of the scientific method applied to the clinic. Both organizational and ethical considerations encourage the use of formal c