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Melan-A/MART-1-specific CD8 T cells: from thymus to tumor

✍ Scribed by Mikaël J Pittet; Alfred Zippelius; Danila Valmori; Daniel E Speiser; Jean-Charles Cerottini; Pedro Romero

Book ID
117787240
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
64 KB
Volume
23
Category
Article
ISSN
1471-4906

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## Abstract MHC class I tetramers containing peptide epitopes are sensitive tools for detecting antigen‐specific CD8^+^ T‐cell responses. We demonstrate here that binding of HLA‐A2 tetramers to CD8^+^ T cells specific for the melanoma‐associated antigen Melan‐A/MART‐1 can be fine‐tuned by altering