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A HLA-Cw*0701 restricted Melan-A/MART1 epitope presented by melanoma tumor cells to CD8+ tumor infiltrating lymphocytes

✍ Scribed by Pierre Larrieu; Virginie Renaud; Yann Godet; Francine Jotereau; Jean-François Fonteneau

Book ID: 105967357
Publisher: Springer-Verlag
Year: 2007
Tongue: English
Weight: 455 KB
Volume: 57
Category: Article
ISSN: 0340-7004
DOI: 10.1007/s00262-007-0436-7

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## Abstract MHC class I tetramers containing peptide epitopes are sensitive tools for detecting antigen‐specific CD8^+^ T‐cell responses. We demonstrate here that binding of HLA‐A2 tetramers to CD8^+^ T cells specific for the melanoma‐associated antigen Melan‐A/MART‐1 can be fine‐tuned by altering