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A HLA-DQ5 restricted Melan-A/MART-1 epitope presented by melanoma tumor cells to CD4+ T lymphocytes

✍ Scribed by Pierre Larrieu; Laure-Hélène Ouisse; Yannick Guilloux; Francine Jotereau; Jean-François Fonteneau

Book ID
105967221
Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
594 KB
Volume
56
Category
Article
ISSN
0340-7004

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Improved detection of melanoma antigen-s
Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue
✍ Markus J. Maeurer; Antje Necker; Russell D. Salter; Chiara Castelli; Hanni Höhn; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 213 KB

## Abstract MHC class I tetramers containing peptide epitopes are sensitive tools for detecting antigen‐specific CD8^+^ T‐cell responses. We demonstrate here that binding of HLA‐A2 tetramers to CD8^+^ T cells specific for the melanoma‐associated antigen Melan‐A/MART‐1 can be fine‐tuned by altering