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Mechanisms of effects of complement inhibition in murine collagen-induced arthritis

✍ Scribed by Nirmal K. Banda; Damian Kraus; Andrea Vondracek; Long H. Huynh; Alison Bendele; V. Michael Holers; William P. Arend

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
188 KB
Volume
46
Category
Article
ISSN
0004-3591

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IL-1 is a key cytokine involved in the inflammatory response. The type II receptor of IL-1 (IL-1RII) acts as a decoy receptor, binding and inhibiting the effect of IL-1. This study was undertaken to establish whether IL-1RII can ameliorate collagen-induced arthritis, a model of inflammatory arthriti