Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis
β Scribed by L. K. Myers; T. Pihlajamaa; D. D. Brand; M. A. Cremer; M. Bodo; L. Ala-Kokko; A. H. Kang
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 100 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0004-3591
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IL-1 is a key cytokine involved in the inflammatory response. The type II receptor of IL-1 (IL-1RII) acts as a decoy receptor, binding and inhibiting the effect of IL-1. This study was undertaken to establish whether IL-1RII can ameliorate collagen-induced arthritis, a model of inflammatory arthriti
## Abstract ## Objective Previous studies have shown that an analog peptide of the immunodominant T cell determinant of type II collagen (CII), i.e., CII^256β276^(N^263^, D^266^), was able to suppress the immune response to CII and the development of arthritis in DR1βtransgenic mice. The present s