## Abstract Chemical reactivity of homocysteine thiolactone (HTL) has been implicated in cardiovascular disease. Owing to its aminoacylโthioester character, HTL undergoes facile electrophilic and nucleophilic reactions at its amino and activatedโcarboxyl group, respectively. To gain insight into th
Mechanism of Hydrolysis and Aminolysis of Homocysteine Thiolactone
โ Scribed by Jonathan Garel; Dan S. Tawfik
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 151 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0947-6539
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๐ SIMILAR VOLUMES
L-[ 35S]Homocysteine thiolactone has been synthesized by demethylation of L-{ 35S]Methionine with sodium in liquid ammonia and subsequent lactonisation in acid solution. The radiochemical yield of the carrier added synthesis was in the range of 45 to 50 % with a radiochemical purity higher than 96 %
## Abstract Optically pure (__R__)โ and (__S__)โ3โaminotetradeuteroโ2โthiophenone (Dโ and Lโ[^2^H~4~]homocysteine thiolactone) for use as substrates for metabolic and pharmacokinetic studies has been prepared. The racemic [^2^H~4~]homocysteine thiolactone hydrochloride was prepared from commerciall
Nucleophilic substitution reactions of cycloalkylmethyl arenesulfonates (C m H 2n ฯช 1 CH 2 OSO 2 C 6 H 4 Z) with anilines (XC 6 H 4 NH 2 ) in methanol at 65.0 ยฐC were studied. The reactivity order (n =4>6>7>5) reflects largely the order of steric effect of the ring size (SEs term) except for n = 5,