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Mechanism of citrinin-induced dysfunction of mitochondria iii. Effects on renal cortical and liver mitochondrial swelling

✍ Scribed by Generoso M. Chagas; Ma. Benigna M. Oliveira; Annibal P. Campello; Ma. Lúcia W. Klüppel

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
497 KB
Volume
15
Category
Article
ISSN
0260-437X

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✦ Synopsis

The effects of the mycotoxin citrinin on renal cortical and liver mitochondrial swelling were studied. Citrinin decreases the rate of swelling induced by the valinomycin-K+ complex, suggesting that the mycotoxin interferes with the mitochondrial membrane fluidity. Citrinin promotes reduction of the amplitude of swelling in the presence of Na+ ions. This alteration reflects interference with complex I of the respiratory chain and ATP synthase complex activity without disarranging the inner mitochondrial membrane, in view of the fact that the shrinkage was not affected. The effect increases with citrinin concentration. Renal tissue is more susceptible than hepatic tissue.

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The inhibition by citrinin (CTN) of lipid peroxidation of mitochondria, sub-mitochondrial particles (SMP) and microsomes was studied. This eect was reversed by the presence of high concentrations of Fe 3 (0 . 4 and 0 . 5 mM), suggesting chelation of the mycotoxin with iron or interference in the red

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The eects of citrinin in the maintenance of the homeostasis of the reactive oxygen species in rat liver cells were evaluated. Citrinin (CTN) modi®es the antioxidant enzymatic defences of cells through the inhibition of GSSGreductase and transhydrogenase. No eect was observed on GSH-peroxidase, catal