Mechanism of citrinin-induced dysfunction of mitochondria. VI. Effect on iron-induced lipid peroxidation of rat liver mitochondria and microsomes

✍ Scribed by Sônia M. R. Ribeiro; Annibal P. Campello; Generoso M. Chagas; Ma. Lúcia W. Klüppel

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 112 KB
• Volume: 16
• Category: Article
• ISSN: 0263-6484
• DOI: 10.1002/(sici)1099-0844(199803)16:1<15::aid-cbf756>3.0.co;2-p

✦ Synopsis

The inhibition by citrinin (CTN) of lipid peroxidation of mitochondria, sub-mitochondrial particles (SMP) and microsomes was studied. This eect was reversed by the presence of high concentrations of Fe 3 (0 . 4 and 0 . 5 mM), suggesting chelation of the mycotoxin with iron or interference in the reduction of Fe 3 .