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Mechanism of citrinin-induced dysfunction of mitochondria. V. Effect on the homeostasis of the reactive oxygen species

✍ Scribed by Sonia M. R. Ribeiro; Generoso M. Chagas; Annibal P. Campello; Ma. Lúcia W. Kluppel

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 149 KB
Volume: 15
Category: Article
ISSN: 0263-6484
DOI: 10.1002/(sici)1099-0844(199709)15:3<203::aid-cbf742>3.0.co;2-j

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✦ Synopsis

The eects of citrinin in the maintenance of the homeostasis of the reactive oxygen species in rat liver cells were evaluated. Citrinin (CTN) modi®es the antioxidant enzymatic defences of cells through the inhibition of GSSGreductase and transhydrogenase. No eect was observed on GSH-peroxidase, catalase, glucose 6-phosphate and 6 phosphogluconate dehydrogenases, and superoxide dismutase. The mycotoxin increased the generation of reactive oxygen species, stimulating the production of the superoxide anion in the respiratory chain. The results suggest that oxidative stress is an important mechanism, side by side with other eects previously shown, in the establishment of the cytotoxicity and cellular death provoked by CTN in several tissues.

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