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Mechanism of action of a benzoylnitrogen mustard derivative of distamycin (FCE24617)

โœ Scribed by Damia, G.; Imperatoril, L.; Coiefl, G.; Erba, E.; Vigano, F.; Popolo, L.; D'Incalci, M.


Book ID
122439353
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
120 KB
Volume
30
Category
Article
ISSN
0959-8049

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N-deformyl-N-~4-N,N-bis(2-chloroethylam~no)benzoyl] distamycin-A (FCE 24517) is a new cytotoxic anti-tumor agent in phase-I clinical trials. We have isolated stable FCE-245 17resistant cell sublines from murine leukemia LIZ10 cells by in vitro exposure to the drug. FCE 245 I 7 selects a mixed popula