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Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517)

โœ Scribed by Capolongo, L; Melegaro, G; Broggini, M; Mongelli, N; Grandi, M


Book ID
109836931
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
713 KB
Volume
68
Category
Article
ISSN
0007-0920

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N-deformyl-N-~4-N,N-bis(2-chloroethylam~no)benzoyl] distamycin-A (FCE 24517) is a new cytotoxic anti-tumor agent in phase-I clinical trials. We have isolated stable FCE-245 17resistant cell sublines from murine leukemia LIZ10 cells by in vitro exposure to the drug. FCE 245 I 7 selects a mixed popula