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Biological profile of FCE 24517, a novel benzoyl mustard analogue of distamycin A

โœ Scribed by Pezzoni, G; Grandi, M; Biasoli, G; Capolongo, L; Ballinari, D; Giuliani, FC; Barbieri, B; Pastori, A; Pesenti, E; Mongelli, N

Book ID
109836676
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
831 KB
Volume
64
Category
Article
ISSN
0007-0920

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N-deformyl-N-~4-N,N-bis(2-chloroethylam~no)benzoyl] distamycin-A (FCE 24517) is a new cytotoxic anti-tumor agent in phase-I clinical trials. We have isolated stable FCE-245 17resistant cell sublines from murine leukemia LIZ10 cells by in vitro exposure to the drug. FCE 245 I 7 selects a mixed popula