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Comparativein vitromyelotoxicity of FCE 24517, a distamycin derivative, to human, canine and murine hematopoietic progenitor cells

โœ Scribed by Donna A. Volpe; De-Lin Du; Maria Grazia Zurlo; Nicola Mongelli; Martin J. Murphy


Publisher
Springer US
Year
1992
Tongue
English
Weight
551 KB
Volume
10
Category
Article
ISSN
0167-6997

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N-deformyl-N-~4-N,N-bis(2-chloroethylam~no)benzoyl] distamycin-A (FCE 24517) is a new cytotoxic anti-tumor agent in phase-I clinical trials. We have isolated stable FCE-245 17resistant cell sublines from murine leukemia LIZ10 cells by in vitro exposure to the drug. FCE 245 I 7 selects a mixed popula