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Measurement of lyophilisation primary drying rates by freeze-drying microscopy

✍ Scribed by S. Zhai; R. Taylor; R. Sanches; N.K.H. Slater


Book ID
108311153
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
428 KB
Volume
58
Category
Article
ISSN
0009-2509

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A commercially available freeze-dry microscopy stage interfaced with an IR microscope is described as a method of in situ measurement of protein secondary structure in the liquid, frozen and freeze-dried states. Studies using solutions of model proteins demonstrated that spectra collected using the