Modeling of freezing step during vial freeze-drying of pharmaceuticals—influence of nucleation temperature on primary drying rate
✍ Scribed by Kyuya Nakagawa; Aurelie Hottot; Severine Vessot; Julien Andrieu
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2011
- Tongue
- English
- Weight
- 124 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1932-2135
- DOI
- 10.1002/apj.424
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The objective of this study was to determine whether a relationship exists between ice nucleation temperature and recovery of activity of a model protein, lactate dehydrogenase, after freeze drying. Aqueous buffer systems containing 50 microg/mL of protein were frozen in vials with externally mounte
The evolution of product temperature and of residual ice content in the various vials of a batch during a freeze-drying process can be significantly affected by local conditions around each vial. In fact, vapor fluid dynamics in the drying chamber determines the local pressure that, taking into acco
A rigorous unsteady state and spatially multidimensional model is presented and solved to describe the dynamic behavior of the primary and secondary drying stages of the lyophilization of a pharmaceutical product in vials for different operational policies. The results in this work strongly motivate
The objective of this study was to determine the in¯uence of ice nucleation temperature on the primary drying rate during lyophilization for samples in vials that were frozen on a lyophilizer shelf. Aqueous solutions of 10% (w/v) hydroxyethyl starch were frozen in vials with externally mounted therm