This report provides, for the first time, a summary of experiments using SMART Freeze Dryer technology during a 9 month testing period. A minimum ice sublimation area of about 300 cm(2) for the laboratory freeze dryer, with a chamber volume 107.5 L, was found consistent with data obtained during pre
Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer
β Scribed by Xiaolin (Charlie) Tang; Steven L. Nail; Michael J. Pikal
- Book ID
- 106492536
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 455 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
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This paper deals with the design space of a pharmaceutical freeze-drying process. Mathematical modeling is used to investigate the effect of the operating conditions [shelf temperature (T shelf ) and chamber pressure (P c )] on product temperature (that has to remain below a limit value) and sublima