The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug
Mean time parameters dealing with the tissue distribution of drugs: Limitations and extensions
โ Scribed by Peter Veng-Pedersen
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 332 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precurso
Based on disposition decomposition analysis (DDA), equations for the mean residence times (MRT) in the body are derived for a drug and its interconversion metabolite that undergo linear tissue distribution and linear or non-linear elimination from the central compartment after non-instantaneous admi