The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug
โฆ LIBER โฆ
The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculations
โ Scribed by Leonid M. Berezhkovskiy
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 426 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0022-3549
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The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi