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A general method for calculating the mean transit times and distribution rate parameters of catenary metabolites

✍ Scribed by Haiyung Cheng

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 341 KB
Volume: 13
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510130304

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✦ Synopsis

A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precursor order and does not require separate administration of the metabolite. The approach is applied to published data for the primary and secondary metabolites of ketamine.

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