Mdr1 Gene Expression and Mutations in Ras Proto-oncogenes in Acute Myeloid Leukemia
β Scribed by Schaich, Markus; Illmer, Thomas
- Book ID
- 111890174
- Publisher
- Informa plc
- Year
- 2002
- Tongue
- English
- Weight
- 260 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1042-8194
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DNA isolated from blood or bone-marrow samples from 18 patients with acute non-lymphocytic leukemia (ANLL) and 14 patients with acute lymphocytic leukemia (ALL) was analyzed for the presence of mutations in the N-ras gene. Using synthetic oligonucleotide probes we detected mutations in 5 cases of AN
Mutations at codon I 2, I 3, and 6 I of the HRAS, KRAS, and NRASgenes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, I 3 in the KRAS gene, a