N-ras gene mutations in acute myeloid leukemia: Accurate detection by solid-phase minisequencing

Analysis of N-ras gene mutations in acut

Analysis of N-ras gene mutations in acute myeloid leukemia by allele specific restriction analysis

✍ A. V. Todd; C. M. Ireland; T. J. Radloff; H. Kronenberg; Dr. H. J. Iland 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 645 KB

## Abstract N‐ras gene activation occurs via single base substitutions in codons 12, 13, and 61. We have developed a rapid screening method, termed allele specific restriction analysis (ASRA), for detection of N‐ras mutations at these three critical codons in acute myeloid leukemia (AML). Patient D