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Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk

✍ Scribed by Jenkins, Mary M.; Reefhuis, Jennita; Gallagher, Margaret L.; Mulle, Jennifer G.; Hoffmann, Thomas J.; Koontz, Deborah A.; Sturchio, Cynthia; Rasmussen, Sonja A.; Witte, John S.; Richter, Patricia; Honein, Margaret A.

Book ID
127014197
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
246 KB
Volume
164
Category
Article
ISSN
1552-4825

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## Abstract The metabolism of xenobiotics is complex and involves multiple steps and multiple enzymes. Genetic variation in the genes encoding these enzymes as well as the level of exposure to the substrates of these enzymes could alter metabolism and clearance of potential carcinogens and thus alt