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Cigarette Smoking, Genetic Variants in Carcinogen-metabolizing Enzymes, and Colorectal Cancer Risk

✍ Scribed by Cleary, S. P.; Cotterchio, M.; Shi, E.; Gallinger, S.; Harper, P.

Book ID: 126873441
Publisher: Oxford University Press
Year: 2010
Tongue: English
Weight: 146 KB
Volume: 172
Category: Article
ISSN: 0002-9262
DOI: 10.1093/aje/kwq245

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## Abstract The metabolism of xenobiotics is complex and involves multiple steps and multiple enzymes. Genetic variation in the genes encoding these enzymes as well as the level of exposure to the substrates of these enzymes could alter metabolism and clearance of potential carcinogens and thus alt