Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate
โ Scribed by F. Pezzetti; M. Martinelli; L. Scapoli; F. Carinci; A. Palmieri; J. Marchesini; P. Carinci; E. Caramelli; R. Rullo; F. Gombos; M. Tognon
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 37 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1059-7794
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## Abstract **BACKGROUND:** Nonsyndromic cleft lip with or without cleft palate (NCL/P) is a common structural malformation with a complex and multifactorial etiology. It has been shown that maternal psychological stress in the periconceptional period can contribute to an increase in the risk of NC
## Abstract ## BACKGROUND Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. Because of the genetic heterogeneity of facial clefts, the aim of this study was to investigate the contribution of previously r
The identification of several putative susceptibility loci for nonsyndromic cleft lip with or without cleft palate (CL f P) has sparked a renewed interest in the genetics of this condition. However, prior to undertaking linkage studies for complex traits such as CL f P it is desirable to have some u