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Mass spectrometry of 3-substituted 4-hydroxyisoquinolines and their derivatives

✍ Scribed by P. B. Terent'ev; N. P. Lomakina; A. N. Kost

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
503 KB
Volume
11
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

Under electron impact, 3‐aryl‐4‐hydroxyisoquinolines form [M – H]^+^, [M – CO]^+^ and [M – H – CO]^+^ ions with a subsequent elimination of HCN or CH~3~CN. A cyclic structure for the [M – H]^+^ ion is suggested. The primary act of fragmentation of the corresponding methyle ether derivatives is the loss of CH~3~⋅, as well as H⋅; the further fragmentatio is similar to that described above. It has been established that the unusual [M – H]^+^, [M – OH]^+^ and [M – CH~5~⋅]^+^ ions are formed when 8 fragments. Fragmentation schemes for all compounds are proposed based upon high resolution mass spectra and deuterated analogues.

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