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Mass spectra of dexamethasone and betamethasone

✍ Scribed by B. A. Lodge; P. Toft


Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
104 KB
Volume
69
Category
Article
ISSN
0022-3549

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Unequivocal distinction between betameth
✍ B. A. Lodge; P. Toft πŸ“‚ Article πŸ“… 1970 πŸ› John Wiley and Sons 🌐 English βš– 203 KB

## Unequivocal Distinction between Betamethasone and Dexamethasone by Mass Spectrometry Keyphrases 0 Dexarnethasone, betarnethasonedistinction, determination c] Mass spectrometry-identity 1 Masssp,ectra were recorded on a Hitachi-Perkin-Elmer model RMU-6D with an ionization voltage of 70ev. The co

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A derwatlzatlon method followed by hquld chromatography (LC) IS described for the determmatlon of the glucocortlcold eplmers of betamethasone and dexamethasone The method 1s based on the dertvatlzatlon of the eplmers with 1-ethoxy-4-(dlchloro-s-trlazmyl)naphthalene m acetomtrde, usmg potassmm carbon

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## Abstract Betamethasone and dexamethasone are two corticosteroids differing in the stereoisomery of their C‐16 methyl group. These two compounds are imperfectly separated by reversed‐phase liquid chromatography and their mass spectra are very similar, leading to a difficult unambiguous identifica