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Determination of betamethasone and dexamethasone by derivitization and liquid chromatography

✍ Scribed by Shou-Mei Wu; Su-Hwei Chen; Hsin-Lung Wu

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
400 KB
Volume
268
Category
Article
ISSN
0003-2670

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✦ Synopsis

A derwatlzatlon method followed by hquld chromatography (LC) IS described for the determmatlon of the glucocortlcold eplmers of betamethasone and dexamethasone The method 1s based on the dertvatlzatlon of the eplmers with 1-ethoxy-4-(dlchloro-s-trlazmyl)naphthalene m acetomtrde, usmg potassmm carbonate as a base catalyst The resultmg denvatwes were readdy separated by normal-phase LC Several parameters that affect the derwatlzatlon are dlscussed The method IS feasible for the determmatlon of betamethasone and dexamethasone m tablets

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Differentiation of betamethasone and dex
Differentiation of betamethasone and dexamethasone using liquid chromatography/positive electrospray tandem mass spectrometry and multivariate statistical analysis
✍ Jean-Philippe Antignac; Bruno Le Bizec; Fabrice Monteau; FranΓ§ois Andre πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 166 KB

## Abstract Betamethasone and dexamethasone are two corticosteroids differing in the stereoisomery of their C‐16 methyl group. These two compounds are imperfectly separated by reversed‐phase liquid chromatography and their mass spectra are very similar, leading to a difficult unambiguous identifica