## Abstract Betamethasone and dexamethasone are two corticosteroids differing in the stereoisomery of their Cโ16 methyl group. These two compounds are imperfectly separated by reversedโphase liquid chromatography and their mass spectra are very similar, leading to a difficult unambiguous identifica
Liquid chromatography mass spectrometry of dexamethasone and betamethasone
โ Scribed by Thomas Cairns; Emil G. Siegmund; John J. Stamp; Jerome P. Skelly
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 523 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1076-5174
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A derwatlzatlon method followed by hquld chromatography (LC) IS described for the determmatlon of the glucocortlcold eplmers of betamethasone and dexamethasone The method 1s based on the dertvatlzatlon of the eplmers with 1-ethoxy-4-(dlchloro-s-trlazmyl)naphthalene m acetomtrde, usmg potassmm carbon
## Unequivocal Distinction between Betamethasone and Dexamethasone by Mass Spectrometry Keyphrases 0 Dexarnethasone, betarnethasonedistinction, determination c] Mass spectrometry-identity 1 Masssp,ectra were recorded on a Hitachi-Perkin-Elmer model RMU-6D with an ionization voltage of 70ev. The co