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Management of Oxidative Stress by Heme Oxygenase-1 in Cisplatin-induced Toxicity in Renal Tubular Cells

✍ Scribed by Schaaf, G.J.; Maas, R.F.M.; de Groene, E.M.; Fink-Gremmels, J.

Book ID
121451357
Publisher
Informa plc
Year
2002
Tongue
English
Weight
303 KB
Volume
36
Category
Article
ISSN
1071-5762

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Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with ␀-amyloid peptide (␀-AP 1-40 ) or hydrogen peroxide (H 2 O 2 ), we detected high levels of reactive oxygen species, accompanied by a significant