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Nitrosative and oxidative stress induced heme oxygenase-1 accumulation in rat mesangial cells

✍ Scribed by Katrin Sandau; Josef Pfeilschifter; Bernhard Brüne

Book ID
119414167
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
210 KB
Volume
342
Category
Article
ISSN
0014-2999

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Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with ␤-amyloid peptide (␤-AP 1-40 ) or hydrogen peroxide (H 2 O 2 ), we detected high levels of reactive oxygen species, accompanied by a significant