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Oxidative stress in zinc-induced dopaminergic neurodegeneration: Implications of superoxide dismutase and heme oxygenase-1

✍ Scribed by Singh, Brajesh Kumar; Kumar, Ashutosh; Ahmad, Israr; Kumar, Vinod; Patel, Devendra Kumar; Jain, Swatantra Kumar; Singh, Chetna


Book ID
123607540
Publisher
Informa plc
Year
2011
Tongue
English
Weight
539 KB
Volume
45
Category
Article
ISSN
1071-5762

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Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with ␀-amyloid peptide (␀-AP 1-40 ) or hydrogen peroxide (H 2 O 2 ), we detected high levels of reactive oxygen species, accompanied by a significant