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Macrolactonization of hydroxy acids using a polymer bound carbodiimide

โœ Scribed by Gary E Keck; Carina Sanchez; Carrie A Wager

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
64 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

An efficient macrolactonization procedure using a polymer bound carbodiimide is described. The procedure uses the polymer supported reagent as a replacement for dicyclohexylcarbodiimide and thus considerably simplifies the workup for such reactions. Partitioning between macrolactone and diolide is shown to depend upon the equivalents of reagent used in cases for which lactonization is difficult.

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