A novel template effect of distannoxane in macrolactonization of ω-hydroxy carboxylic acids
✍ Scribed by Junzo Otera; Toru Yano; Yasuyuki Himeno; Hitosi Nozaki
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 217 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A variety of lactones were prepared in high yields at room temperature from the corresponding v-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine. A similar reaction also occurs with triethylamine when using a catalytic amount of 4-(dimethyl
## In terms of solvophobicity, acetonftrfk is selected OS a solvent to get accem to macroiactamization of cu-(p-aminophenyl) carboxylic acids (la-e) by using 2,2'-dipyridyIdimdjIdetriphenylphpht a8 an activating reagent. The yields of am-macrolactams (2% b, c, e) are 58-70%.