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M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

✍ Scribed by De Souza, Angus T.; Hankins, Gerald R.; Washington, Mary K.; Orton, Terry C.; Jirtle, Randy L.

Book ID: 109918894
Publisher: Nature Publishing Group
Year: 1995
Tongue: English
Weight: 549 KB
Volume: 11
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng1295-447

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## Abstract To elucidate whether the M6p/Igf2 receptor (M6p/Igf2r) gene might be involved in exogenous and endogenous liver carcinogenesis, we investigated its alteration in hepatocellular carcinomas (HCCs) induced by __N__‐nitrosodiethylamine (DEN) and by a choline‐deficient L‐amino acid‐defined (