## Abstract The human protein MED1, also known as MBD4, was isolated in a yeast twoβhybrid screening as an interactor of the mismatch repair protein MLH1. MED1 contains an Nβterminal 5βmethylcytosine binding domain (MBD), which allows binding to methylated DNA, and a Cβterminal catalytic domain wit
β¦ LIBER β¦
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability
β Scribed by Bellacosa, Alfonso; Riccio, Antonio; Aaltonen, Lauri A.; Godwin, Andrew K.; Loukola, Anu; Percesepe, Antonio; Salovaara, Reijo; Masciullo, Valeria; Genuardi, Maurizio; Paravatou-Petsotas, Maria; Bassi, Daniel E.; Ruggeri, Bruce A.; Klein-Szanto, Andres J.P.; Testa, Joseph R.; Neri, Giovanni
- Book ID
- 109544546
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 232 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/15443
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Role of MED1 (MBD4) Gene in DNA repair a
β
Alfonso Bellacosa
π
Article
π
2001
π
John Wiley and Sons
π
English
β 230 KB
π 1 views
Four new mutations in the DNA mismatch r
β
Klaus K.-F. Herfarth; Olagunju A. Ogunbiyi; Jeffrey F. Moley; Ira J. Kodner; Sam
π
Article
π
1998
π
John Wiley and Sons
π
English
β 35 KB
π 2 views
Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with inherited mutation in one of four DNA mismatch repair genes. Somatic mutations in the same genes are also found in a subset of sporadic colorectal cancers. A defect in DNA mismatch repair results in an RER (replication e
Mutational Analysis of Mismatch Repair G
β
Kobayashi, Kanji ;Matsushima, Mieko ;Koi, Sumiko ;Saito, Hiroko ;Sagae, Satoru ;
π
Article
π
1996
π
Wiley (Blackwell Publishing)
π
English
β 315 KB
Analysis for microsatellite instability
β
Gisela Keller; Volker Grimm; Holger Vogelsang; Petra Bischoff; James Mueller; JΓΆ
π
Article
π
1996
π
John Wiley and Sons
π
French
β 638 KB
Hypermethylation of the hMLH1 gene promo
β
Fleisher, A Steven; Esteller, Manel; Tamura, Gen; Rashid, Asma; Stine, O Colin;
π
Article
π
2001
π
Nature Publishing Group
π
English
β 326 KB
Mutation in the DNA mismatch repair gene
β
Bronner, C. Eric; Baker, Sean M.; Morrison, Paul T.; Warren, Gwynedd; Smith, Les
π
Article
π
1994
π
Nature Publishing Group
π
English
β 563 KB