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The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

✍ Scribed by Bellacosa, Alfonso; Riccio, Antonio; Aaltonen, Lauri A.; Godwin, Andrew K.; Loukola, Anu; Percesepe, Antonio; Salovaara, Reijo; Masciullo, Valeria; Genuardi, Maurizio; Paravatou-Petsotas, Maria; Bassi, Daniel E.; Ruggeri, Bruce A.; Klein-Szanto, Andres J.P.; Testa, Joseph R.; Neri, Giovanni


Book ID
109544546
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
232 KB
Volume
23
Category
Article
ISSN
1061-4036

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## Abstract The human protein MED1, also known as MBD4, was isolated in a yeast two‐hybrid screening as an interactor of the mismatch repair protein MLH1. MED1 contains an N‐terminal 5‐methylcytosine binding domain (MBD), which allows binding to methylated DNA, and a C‐terminal catalytic domain wit

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