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M6P/IGF2R is mutated in squamous cell carcinoma of the lung

✍ Scribed by Kong, Feng-Ming; Anscher, Mitchell S; Washington, Mary K; Killian, J Keith; Jirtle, Randy L

Book ID
110062782
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
363 KB
Volume
19
Category
Article
ISSN
0950-9232

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## Abstract The mannose 6‐phosphate/insulin‐like growth factor 2 receptor (M6P/IGF2r), a member of the IGF axis of growth factors, is a negative regulator of cell growth and a putative tumor suppressor gene. Regulation of M6P/IGF2r levels is critical in breast physiology; low expression is associat