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Lymphoproliferative disorders in Sotos syndrome: Observation of two cases

✍ Scribed by Corsello, Giovanni; Giuffrè, Mario; Carcione, Aldo; Cuzto, Margherita L.; Piccione, Maria; Ziino, Ottavio

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
532 KB
Volume
64
Category
Article
ISSN
0148-7299

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✦ Synopsis

Sotos syndrome is included among the overgrowth disorders, most of which have an increased risk of neoplasms. Sotos syndrome does not appear to be related to a specific tumor type, but rather to the development of solid tumors of ectodermal or mesodermal origin in general. We report on two Sotos syndrome patients who developed a non-Hodgkin lymphoma and an acute lymphoblastic leukaemia, respectively. Our experience suggests that there may exist a high frequency of lymphoproliferative disorders in Sotos syndrome, and points out the importance of a long-term follow-up of Sotos syndrome patients, to detect a possible neoplastic evolution. 01996 Wiley-Liss, Inc.

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