✦ LIBER ✦

Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder: Response to chemotherapy in two cases

✍ Scribed by Gordon, Leo I. ;Hrushesky, William ;Oken, Martin M. ;Kay, Neil E. ;Rydell, Robert E.

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 398 KB
Volume: 7
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950070203

No coin nor oath required. For personal study only.

✦ Synopsis

The development of either histiocytic lymphoma or Hodgkin disease in association with pre-existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.

📜 SIMILAR VOLUMES

Response of agranulocytosis to thymectom

Response of agranulocytosis to thymectomy in a patient with thymoma and chronic lymphocytic leukemia

✍ Weir, Alva B. ;Dow, Lois W. 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB

A patient with chronic lymphocytic leuke-Both autologous and heterologous granulomia presented with recurrent episodes of cyte macrophage colony growth were severe neutropenia. This neutropenia was clearly inhibited by the patient's serum. This initially responsive to prednisone but evenis the first

Reply to tumor flare reaction associated

Reply to tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response

✍ Aisha Masood; Taimur Sher; Asher Chanan-Khan 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 708 KB

Recurrent skin reaction secondary to dar

Recurrent skin reaction secondary to darbepoetin alfa for two months in a patient with chronic lymphocytic leukemia

✍ Fadi I. Jabr; Ali Taher 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB 👁 2 views

Transient response of pure red cell apla

Transient response of pure red cell aplasia to anti-thymocyte globulin in a patient with T-cell chronic lymphocytic leukemia

✍ Dr. William Hocking; Richard Champlin; Ronald Mitsuyasu 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB 👁 3 views

Pure red cell aplasia (PRCA) is an unusual complication of chronic lymphoproliferative disorders. A patient with T-cell chronic lymphocytic leukemia (T-CLL) had severe anemia and neutropenia. Initial in vitro studies demonstrated no evidence of T-cell suppression of erythropoiesis. Sequential bone m

Lymphopenic response of patients present

Lymphopenic response of patients presenting with chronic lymphocytic leukemia associated with carcinoma of the prostate to diethylstilbestrol: Correlation of response to the in vitro synthesis of rna by patient lymphocytes and its relationship to transcortin

✍ Parthasarathy Narasimhan; Leonard Amaral 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB 👁 2 views

Transient response to imatinib in a chro

Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene

✍ Christoph Walz; Claire Curtis; Susanne Schnittger; Beate Schultheis; Georgia Met 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB

## Abstract Chronic myeloproliferative disorders with rearrangements of the platelet‐derived growth factor receptor A (__PDGFRA__) gene at chromosome band 4q12 have shown excellent responses to targeted therapy with imatinib. Here we report a female patient who presented with advanced phase of a ch