Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the av
Lymphatic system changes in diabetes mellitus: role of insulin and hyperglycemia
β Scribed by P. Moriguchi; P. Sannomiya; P. F. Lara; R. M. Oliveira-Filho; K. V. Greco; L. S. Sudo-Hayashi
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 146 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1520-7552
- DOI
- 10.1002/dmrr.500
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## Abstract Complications associated with insulinβdependent diabetes mellitus (typeβ1diabetes) primarily represent vascular dysfunction that has its origin in the endothelium. While many of the vascular changes are more accountable in the late stages of typeβ1diabetes, changes that occur in the ear