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Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype


Book ID
122852245
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
156 KB
Volume
6
Category
Article
ISSN
0169-5002

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Debrisoquine hydroxylation exhibits wide inter-individual variation in Caucasian populations. After similar doses of the drug, extensive metabolizers excrete up to several hundred times more of the urinary metabolite 4-hydroxy-debrisoquine than do poor metabolizers. The phenotypes have traditionally