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Lung cancer and the debrisoquine metabolic phenotype


Book ID
122770114
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
173 KB
Volume
7
Category
Article
ISSN
0169-5002

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The distribution of debrisoquine metabol
โœ Neil Caporaso; Linda Williams Pickle; Sherri Bale; Riad Ayesh; Martin Hetzel; Je ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 504 KB

Debrisoquine hydroxylation exhibits wide inter-individual variation in Caucasian populations. After similar doses of the drug, extensive metabolizers excrete up to several hundred times more of the urinary metabolite 4-hydroxy-debrisoquine than do poor metabolizers. The phenotypes have traditionally