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The Debrisoquine Metabolic Phenotype and DNA-Based Assays: Implications of Misclassification for the Association of Lung Cancer and the Debrisoquine Metabolic Phenotype

โœ Scribed by N. E. Caporaso, P. G. Shields, M. T. Landi, G. L. Shaw, M. A. Tucker, R. Hoover, H. Sugimura, A. Weston and C. C. Harris

Book ID
124295578
Publisher
Environmental Health Information Service
Year
1992
Tongue
English
Weight
233 KB
Volume
98
Category
Article
ISSN
0091-6765

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The distribution of debrisoquine metabol
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โœ Neil Caporaso; Linda Williams Pickle; Sherri Bale; Riad Ayesh; Martin Hetzel; Je ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 504 KB

Debrisoquine hydroxylation exhibits wide inter-individual variation in Caucasian populations. After similar doses of the drug, extensive metabolizers excrete up to several hundred times more of the urinary metabolite 4-hydroxy-debrisoquine than do poor metabolizers. The phenotypes have traditionally