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Loss of imprinting marks predisposition to colorectal cancer?

✍ Scribed by Stephen A. Bustin


Book ID
114382301
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
46 KB
Volume
5
Category
Article
ISSN
1357-4310

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## Abstract Loss of imprinting (LOI) of insulin‐like growth factor 2 (__IGF2__) is a common event in many cancers and typically activates the maternally silenced allele. The resulting biallelic __IGF2__ expression correlates strongly with the hypomethylation of a differentially methylated region (D