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IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer

✍ Scribed by Randy L. Jirtle

Book ID
119757669
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
92 KB
Volume
126
Category
Article
ISSN
0016-5085

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## Abstract Loss of imprinting (LOI) of insulin‐like growth factor 2 (__IGF2__) is a common event in many cancers and typically activates the maternally silenced allele. The resulting biallelic __IGF2__ expression correlates strongly with the hypomethylation of a differentially methylated region (D