## Abstract Loss of imprinting (LOI), the biallelic expression of an imprinting gene, of insulinβlike growth factor 2 (__IGF2__) has been reported to be associated with colorectal carcinogenesis because of its high prevalence in normal colorectal mucosa as well as cancerous tissue in patients with
Loss of imprinting of the insulin-like growth factor 2 gene and risk of colorectal cancer
β Scribed by Ronghua Zhao; Marcia Cruz-Correa
- Book ID
- 107535687
- Publisher
- Current Science Inc.
- Year
- 2008
- Tongue
- English
- Weight
- 271 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1556-3790
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## Abstract This study examined the frequency of loss of imprinting (LOI) and expression of the insulinβlike growth factor 2 (__IGF2__) gene, and their relationship to selected clinical and pathological factors, in a well defined series of 90 Chinese patients with gastric cancer (GC) and 90 matched
Paternal allele-specific expression is identified for the insulinlike growth factor 2 (IGFZ) gene. Relaxation or loss of IGFZ imprinting, however, has been reported in several neoplasms. We studied the expression of IGFZ mRNA in 35 s q w m w s cancers of the esophagus and searched for the presence
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