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T2082 Loss of IGF-2 Genomic Imprinting and Increased Risk of Colorectal Neoplasia Recurrence: A Prospective Cohort Study

✍ Scribed by Cruz-Correa, Marcia R.; Wang, Hao; Hylind, Linda; Zhao, Ronghua; Berho, Mariana; Sands, Dana; Weiss, Eric G.; Nogueras, Juan; Wexner, Steven; Giardiello, Francis M.

Book ID: 122607596
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 63 KB
Volume: 134
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(08)62872-3

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## Abstract Chronically elevated plasma insulin levels have been postulated to increase colon cancer risk, either directly through colonic insulin receptors or indirectly through downregulation of IGFBP‐1 and/or IGFBP‐2, thus increasing IGF activity. Our aim was to examine the relationships of plas